Emerging opportunities and career paths for the young physician-scientist
in: Nature medicine . - New York, NY : Nature America Inc., ISSN 1546-170X, Vol. 8, No. 5 (2002), p. 437-439 Zugang:
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Paradoxical Effect of Phlorizin on Glucose Uptake and Intracellular Accumulation of Amino-Acids in Rat Kidney Slices in vitro
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 192, No. 4807 (1961), p. 1085-1086 Zugang:
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1961
THE discovery by von Mering1 that phlorizin causes glycosuria in the dog and the observation that phlorizin prevents renal tubular re-absorption of glucose2,3 have evoked considerable interest in this substance as a tool in the investigation of cellular transport mechanisms. Much work with... mehr
Inborn errors of cobalamin metabolism: Effect of cobalamin supplementation in culture on methylmalonyl CoA mutase activity in normal and mutant human fibroblasts
in: Biochemical genetics , ISSN 1573-4927, Vol. 17 (1/2. 1979), p. 57-75 Zugang:
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1979
Abstract We have examined the effect of addition of hydroxocobalamin to growth medium on the activity of the adenosylcobalamin-requiring enzyme methylmalonyl CoA mutase in normal human fibroblasts and in mutant human fibroblasts derived from patients with inherited methylmalonicacidemia. The... mehr
Copyright: Copyright 1979 Plenum Publishing Corporation mehr
Effect of Puromycin on Insulin-stimulated Amino-acid Transport in Muscle
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 214, No. 5091 (1967), p. 916-917 Zugang:
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1967
INSULIN stimulates both the transport1,2 of amino-acids and their incorporation3 into protein in skeletal muscle. Previous attempts to associate these two effects have failed4–7. That is, inhibition of new protein synthesis by puromycin did not impair the stimulatory effect of insulin on... mehr
Genetically controlled IgM hyporesponsiveness to aK. pneumoniae polysaccharide
in: Immunogenetics , ISSN 1432-1211, Vol. 6 (1. 1978), p. 81-89 Zugang:
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1978
Abstract Examination of the immune response to aKlebsiella pneumoniae polysaccharide (K47-PS) has revealed that BALB/c mice demonstrate only a very weak primary response to this antigen. The low response does not result from either a peculiar dose response curve for BALB/c mice or from differing... mehr
Copyright: Copyright 1978 Springer-Verlag New York Inc. mehr
Gene deletion and restriction fragment length polymorphisms at the human ornithine transcarbamylase locus
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 313, No. 6005 (1985), p. 815-817 Zugang:
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1985
Deficiency of ornithine transcarbamylase (OTC; EC 2.1.3.3), a hepatic mitochondrial enzyme involved in the detoxification of ammonia1,2, is a severe inborn error of metabolism. It is an X-linked disorder2–4 which results characteristically in ammonia intoxication, protein intolerance and mental... mehr
Rapid prenatal and postnatal detection of inborn errors of propionate, methylmalonate, and cobalamin metabolism: A sensitive assay using cultured cells
in: Human genetics , ISSN 1432-1203, Vol. 34 (3. 1976), p. 277-283 Zugang:
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1976
Summary A sensitive, reliable, and easily performed procedure is described for the prenatal and postnatal detection of inborn errors of propionate, methylmalonate, and cobalamin metabolism using cultured amniotic cells and skin fibroblasts. With this assay, control fibroblast lines incorporated a... mehr
Fourth metting of the European Neurological Society 25–29 June 1994 Barcelona, Spain
in: Journal of neurology , ISSN 1432-1459, Vol. 241 (1. 1994), p. 1-164 Zugang:
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