Disruption of an imprinted gene cluster by a targeted chromosomal translocation in mice
in: Nature genetics . - New York, NY : Nature America, ISSN 1546-1718, Vol. 29, No. 1 (2001), p. 78-82 Zugang:
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2001
Genomic imprinting is an epigenetic process in which the activity of a gene is determined by its parent of origin. Mechanisms governing genomic imprinting are just beginning to be understood. However, the tendency of imprinted genes to exist in chromosomal clusters suggests a sharing of... mehr
Effects of G-protein mutations on skin color
in: Nature genetics . - New York, NY : Nature America, ISSN 1546-1718, Vol. 36, No. 9 (2004), p. 961-968 Zugang:
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2004
A new class of dominant dark skin (Dsk) mutations discovered in a screen of ∼30,000 mice is caused by increased dermal melanin. We identified three of four such mutations as hypermorphic alleles of Gnaq and Gna11, which encode widely expressed Gαq subunits, act in an additive and quantitative... mehr
The development of a new approach for establishing a core collection using multivariate analyses with tulip as case
in: Genetic resources and crop evolution , ISSN 1573-5109, Vol. 47 (4. 2000), p. 403-416 Zugang:
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2000
Abstract A methodology is developed for the establishment of a core collection based on phenotypic data. A case is worked out for the tulip cultivar collection of the Hortus Bulborum, consisting of approximately 1000 cultivars. The methodology is based on cluster analysis of phenetic characters,... mehr
Copyright: Copyright 2000 Kluwer Academic Publishers mehr
Phylogeny reconstruction and hybrid analysis in Allium subgenus Rhizirideum
in: Theoretical and applied genetics , ISSN 1432-2242, Vol. 100 (7. 2000), p. 1000-1009 Zugang:
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2000
Abstract Amplified fragment length polymorphisms (AFLPs) for assessing nuclear DNA diversity have been used for the reconstruction of the phylogeny and evolution of several sections of Allium subgenus Rhizirideum. A dataset of 355 characters for 33 accessions belonging to 20 species has been... mehr
Copyright: Copyright 2000 Springer-Verlag Berlin Heidelberg mehr
Pigment composition of flowers of Tulipa species as a parameter for biosystematic research
in: Biochemical Systematics and Ecology, in: Biochemical Systematics and Ecology . - Amsterdam : Elsevier, ISSN 0305-1978, ZDB-ID 1499902-X Vol. 18, No. 6 (1990), p. 399-404
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1990
Copyright: Copyright (c) 2002 Elsevier Science Ltd mehr
Mitochondrial DNA variation and crossability of leek (Allium porrum) and its wild relatives from the Allium ampeloprasum complex
in: Theoretical and applied genetics , ISSN 1432-2242, Vol. 94 (3/4. 1997), p. 465-471 Zugang:
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1997
Abstract Mitochondrial (mt) DNA variation in the cultigens leek, kurrat and prei-anak is limited compared to that of their wild relatives in the Allium ampeloprasum complex. The phylogenetic relationships among these cultigens and their wild relatives is quite close, with the majority of the... mehr
Copyright: Copyright 1997 Springer-Verlag Berlin Heidelberg mehr
Ovalbumin messenger ribonucleic acid accumulation in the chick oviduct during secondary stimulation: influence of combinations of steroid hormones and circannual rhythms
In: Biochemistry. - Columbus, Ohio : American Chemical Society, ISSN 1520-4995, Vol. 19, No. 7 (1980), p. 1410-1416 Zugang:
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PAX6 haploinsufficiency causes cerebral malformation and olfactory dysfunction in humans
in: Nature genetics . - New York, NY : Nature America, ISSN 1546-1718, Vol. 28, No. 3 (2001), p. 214-216 Zugang:
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2001
PAX6 is widely expressed in the central nervous system. Heterozygous PAX6 mutations in human aniridia cause defects that would seem to be confined to the eye. Magnetic resonance imaging (MRI) and smell testing reveal the absence or hypoplasia of the anterior commissure and reduced olfaction in a... mehr
Low-penetrance susceptibility to breast cancer due to CHEK2<sup>*</sup>1100delC in noncarriers of BRCA1 or BRCA2 mutations
in: Nature genetics . - New York, NY : Nature America, ISSN 1546-1718, Vol. 31, No. 1 (2002), p. 55-59 Zugang:
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2002
Mutations in BRCA1 and BRCA2 confer a high risk of breast and ovarian cancer, but account for only a small fraction of breast cancer susceptibility. To find additional genes conferring susceptibility to breast cancer, we analyzed CHEK2 (also known as CHK2), which encodes a cell-cycle checkpoint... mehr
Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 402, No. 6763 (1999), p. 761-768 Zugang:
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1999
Arabidopsis thaliana (Arabidopsis) is unique among plant model organisms in having a small genome (130–140 Mb), excellent physical and genetic maps, and little repetitive DNA. Here we report the sequence of chromosome 2 from the Columbia ecotype in two gap-free assemblies (contigs) of 3.6 and... mehr
A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 409, No. 6822 (2001), p. 928-933 Zugang:
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2001
We describe a map of 1.42 million single nucleotide polymorphisms (SNPs) distributed throughout the human genome, providing an average density on available sequence of one SNP every 1.9 kilobases. These SNPs were primarily discovered by two projects: The SNP Consortium and the analysis of clone... mehr
Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 408, No. 6814 (2000), p. 816-820 Zugang:
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2000
The genome of the flowering plant Arabidopsis thaliana has fivechromosomes. Here we report the sequence of the largest,chromosome 1, in two contigs of around 14.2 and 14.6 megabases. The contigsextend from the telomeres to the centromeric borders, regions rich in transposons,retrotransposons and... mehr
Mapping autism risk loci using genetic linkage and chromosomal rearrangements
in: Nature genetics . - New York, NY : Nature America, ISSN 1546-1718, Vol. 39, No. 3 (2007), p. 319-328 Zugang:
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2007
Autism spectrum disorders (ASDs) are common, heritable neurodevelopmental conditions. The genetic architecture of ASDs is complex, requiring large samples to overcome heterogeneity. Here we broaden coverage and sample size relative to other studies of ASDs by using Affymetrix 10K SNP arrays and... mehr
Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 432, No. 7018 (2004), p. 695-716 Zugang:
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2004
We present here a draft genome sequence of the red jungle fowl, Gallus gallus. Because the chicken is a modern descendant of the dinosaurs and the first non-mammalian amniote to have its genome sequenced, the draft sequence of its genome—composed of approximately one billion base pairs of... mehr
Genome-wide association study identifies novel breast cancer susceptibility loci
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 447, No. 7148 (2007), p. 1087-1093 Zugang:
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2007
Breast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility to the disease. Known susceptibility genes account for less than 25% of the familial risk of breast cancer, and the residual genetic variance is likely to be due to variants conferring more moderate... mehr
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 447, No. 7146 (2007), p. 799-816 Zugang:
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2007
We report the generation and analysis of functional data from multiple, diverse experiments performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE Project. These data have been further integrated and augmented by a number of evolutionary and computational... mehr