Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 446, No. 7137 (2007), p. 806-810 Zugang:
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2007
Defining the functional relationships between proteins is critical for understanding virtually all aspects of cell biology. Large-scale identification of protein complexes has provided one important step towards this goal; however, even knowledge of the stoichiometry, affinity and lifetime of... mehr
A physical map of the chicken genome
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 432, No. 7018 (2004), p. 761-764 Zugang:
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2004
Strategies for assembling large, complex genomes have evolved to include a combination of whole-genome shotgun sequencing and hierarchal map-assisted sequencing. Whole-genome maps of all types can aid genome assemblies, generally starting with low-resolution cytogenetic maps and ending with the... mehr
The Collaborative Cross, a community resource for the genetic analysis of complex traits
in: Nature genetics . - New York, NY : Nature America, ISSN 1546-1718, Vol. 36, No. 11 (2004), p. 1133-1137 Zugang:
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2004
The goal of the Complex Trait Consortium is to promote the development of resources that can be used to understand, treat and ultimately prevent pervasive human diseases. Existing and proposed mouse resources that are optimized to study the actions of isolated genetic loci on a fixed background... mehr
Genome-wide atlas of gene expression in the adult mouse brain
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 445, No. 7124 (2007), p. 168-176 Zugang:
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2007
Molecular approaches to understanding the functional circuitry of the nervous system promise new insights into the relationship between genes, brain and behaviour. The cellular diversity of the brain necessitates a cellular resolution approach towards understanding the functional genomics of the... mehr
The International HapMap Project
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 426, No. 6968 (2003), p. 789-796 Zugang:
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2003
The goal of the International HapMap Project is to determine the common patterns of DNA sequence variation in the human genome and to make this information freely available in the public domain. An international consortium is developing a map of these patterns across the genome by determining the... mehr
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 447, No. 7146 (2007), p. 799-816 Zugang:
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2007
We report the generation and analysis of functional data from multiple, diverse experiments performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE Project. These data have been further integrated and augmented by a number of evolutionary and computational... mehr