Kinetic characterization of the polymerase and exonuclease activities of the gene 43 protein of bacteriophage T4
In: Biochemistry. - Columbus, Ohio : American Chemical Society, ISSN 1520-4995, Vol. 31, No. 45 (1992), p. 10984-10994 Zugang:
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In Situ Mixed Region Vapor Stripping in Low-Permeability Media. 2. Full-Scale Field Experiments
In: Environmental science & technology. - Columbus, Ohio : American Chemical Society, ISSN 1520-5851, Vol. 29, No. 9 (1995), p. 2198-2207 Zugang:
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Effect of similions on the coagulation of silver bromide sols in statu nascendi
In: The journal of physical chemistry . - Washington, DC : American Chemical Society, Vol. 71, No. 9 (1967), p. 3057-3059 Zugang:
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Filled liquid crystal depolarizers
In: Journal of Applied Physics. - [S.l.], ISSN 1089-7550, Vol. 90, No. 8 (2001), p. 3675-3678 Zugang:
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2001
The construction and properties of scattering type liquid crystal depolarizers are discussed. The Mueller matrices that describe these devices are measured and compared to ideal depolarizers and ideal linear materials. The present depolarizers do not perform as well as crystal pseudodepolarizers.... mehr
Total synthesis of (.+-.)-calanolide A, a non-nucleoside inhibitor of HIV-1 reverse transcriptase
In: The journal of organic chemistry. - [S.l.] : American Chemical Society, ISSN 1520-6904, Vol. 58, No. 21 (1993), p. 5605-5606 Zugang:
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Mediastinal tumors in children: Experience with 196 cases
in: Annals of surgical oncology , ISSN 1534-4681, Vol. 1 (2. 1994), p. 121-127 Zugang:
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1994
Abstract Background: Mediastinal masses are relatively common in infants and children. These lesions are often neoplastic in origin and have a high risk of malignancy. Methods: This report concerns 196 infants and children with mediastinal tumors. Fifty-five cases (28%) were benign, and 141 (72%)... mehr
Copyright: Copyright 1994 The Society of Surgical Oncology, Inc. mehr
NMR solution structure of the RNA-binding peptide from HIV-1 Rev protein
In: Biochemistry. - Columbus, Ohio : American Chemical Society, ISSN 1520-4995, Vol. 34, No. 26 (1995), p. 8242-8249 Zugang:
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Gastrointestinal tumors in children: An analysis of 39 cases
in: Annals of surgical oncology , ISSN 1534-4681, Vol. 1 (4. 1994), p. 283-289 Zugang:
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1994
Abstract Background: Gastrointestinal tumors are relatively uncommon in infants and children, and the histologic diagnoses differ from those seen in an adult practice. Furthermore, the clinical presentation of such tumors is quite variable. Methods: We reviewed the records of 39 pediatric... mehr
Copyright: Copyright 1994 The Society of Surgical Oncology, Inc mehr
RNA polymerase II C-terminal domain required for enhancer-driventranscription
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 374, No. 6523 (1995), p. 660-662 Zugang:
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1995
THE RNA polymerase II carboxy-terminal domain (CTD) consists of tandem repeats of the sequence Tyr-Ser-Pro-Thr-Ser-Pro-Ser1–3. The CTD may participate in activated transcription through interaction with a high-molecular-weight mediator complex4–6. Such a role would be consistent with... mehr
Photoelectron Spectroscopy of a Carbene/Silylene/Germylene Series
In: American Chemical Society: Journal of the American Chemical Society. - Washington, DC : American Chemical Society, ISSN 1520-5126, Vol. 116, No. 15 (1994), p. 6641-6649 Zugang:
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Expression profiling using microarrays fabricated by an ink-jet oligonucleotide synthesizer
in: Nature biotechnology . - New York, NY : Nature America, ISSN 1546-1696, Vol. 19, No. 4 (2001), p. 342-347 Zugang:
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2001
We describe a flexible system for gene expression profiling using arrays of tens of thousands of oligonucleotides synthesized in situ by an ink-jet printing method employing standard phosphoramidite chemistry. We have characterized the dependence of hybridization specificity and sensitivity on... mehr
Patterns of somatic mutation in human cancer genomes
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 446, No. 7132 (2007), p. 153-158 Zugang:
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2007
Cancers arise owing to mutations in a subset of genes that confer growth advantage. The availability of the human genome sequence led us to propose that systematic resequencing of cancer genomes for mutations would lead to the discovery of many additional cancer genes. Here we report more than... mehr
Lung cancer: Intragenic ERBB2 kinase mutations in tumours
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 431, No. 7008 (2004), p. 525-526 Zugang:
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2004
The protein-kinase family is the most frequently mutated gene family found in human cancer and faulty kinase enzymes are being investigated as promising targets for the design of antitumour therapies. We have sequenced the gene encoding the transmembrane protein tyrosine kinase ERBB2 (also known... mehr
A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer
in: Nature genetics . - New York, NY : Nature America, ISSN 1546-1718, Vol. 37, No. 6 (2005), p. 590-592 Zugang:
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2005
We examined the coding sequence of 518 protein kinases, ∼1.3 Mb of DNA per sample, in 25 breast cancers. In many tumors, we detected no somatic mutations. But a few had numerous somatic mutations with distinctive patterns indicative of either a mutator phenotype or a past exposure. mehr
Initial sequencing and comparative analysis of the mouse genome
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 420, No. 6915 (2002), p. 520-562 Zugang:
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2002
The sequence of the mouse genome is a key informational tool for understanding the contents of the human genome and a key experimental tool for biomedical research. Here, we report the results of an international collaboration to produce a high-quality draft sequence of the mouse genome. We also... mehr
Genome-wide association study identifies novel breast cancer susceptibility loci
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 447, No. 7148 (2007), p. 1087-1093 Zugang:
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2007
Breast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility to the disease. Known susceptibility genes account for less than 25% of the familial risk of breast cancer, and the residual genetic variance is likely to be due to variants conferring more moderate... mehr
The DNA sequence of the human X chromosome
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 434, No. 7031 (2005), p. 325-337 Zugang:
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2005
The human X chromosome has a unique biology that was shaped by its evolution as the sex chromosome shared by males and females. We have determined 99.3% of the euchromatic sequence of the X chromosome. Our analysis illustrates the autosomal origin of the mammalian sex chromosomes, the stepwise... mehr