Gene and genome scanning by two-dimensional DNA typing
in: Electrophoresis, in: Electrophoresis . - Weinheim : Wiley-VCH, ISSN 0173-0835, ZDB-ID 1475486-1 Vol. 16 (1. 1995), p. 186-196
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1995
A major effort in the analysis of DNA currently focuses on identifying genes and their pathological variants underlying disease. Once such disease genes have been isolated a major task of molecular medicine is to identify the spectrum of DNA sequence variations responsible for the aberrant... mehr
Denaturing gradient gel electrophoretic analysis of minisatellite alleles
in: Electrophoresis, in: Electrophoresis . - Weinheim : Wiley-VCH, ISSN 0173-0835, ZDB-ID 1475486-1 Vol. 12 (1. 1991), p. 12-16
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1991
By two-dimensional DNA fingerprinting, an electrophoretic method which combines separation according to size with separation in a denaturing gradient, virtually all minisatellite sequences detected with a minisatellite core probe can be resolved (Uitterlinden et al., Proc. Natl. Acad. Sci. USA.... mehr
Genome scanning by two-dimensional DNA typing: The use of repetitive DNA sequences for rapid mapping of genetic traits
in: Electrophoresis, in: Electrophoresis . - Weinheim : Wiley-VCH, ISSN 0173-0835, ZDB-ID 1475486-1 Vol. 12 (2-3. 1991), p. 119-134
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1991
The existence of repetitive DNA sequences offers the possibility to assess the mammalian genome for individual variation in its entirety rather than at one or only a few sites. In order to fully explore the various sets of mammalian repeat sequences for this purpose, analytical tools are required... mehr
Population analysis of the collagen type IIα1 3′ variable number of tandem repeat polymorphism by heteroduplex genotyping
in: Electrophoresis, in: Electrophoresis . - Weinheim : Wiley-VCH, ISSN 0173-0835, ZDB-ID 1475486-1 Vol. 19 (5. 1998), p. 661-666
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1998
The AT-rich variable number of tandem repeat (VNTR) marker at the 3′ end of the collagen type IIα1 (COL2A1) gene has been shown to have a complex structure with extensive sequence variations among repeat units. We analyzed this VNTR polymorphism in a large population of 972 Caucasian... mehr
A road map for efficient and reliable human genome epidemiology
in: Nature genetics . - New York, NY : Nature America, ISSN 1546-1718, Vol. 38, No. 1 (2006), p. 3-5 Zugang:
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2006
Networks of investigators have begun sharing best practices, tools and methods for analysis of associations between genetic variation and common diseases. A Network of Investigator Networks has been set up to drive the process, sponsored by the Human Genome Epidemiology Network. A workshop is... mehr
Genome-wide association study identifies novel breast cancer susceptibility loci
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 447, No. 7148 (2007), p. 1087-1093 Zugang:
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2007
Breast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility to the disease. Known susceptibility genes account for less than 25% of the familial risk of breast cancer, and the residual genetic variance is likely to be due to variants conferring more moderate... mehr