Thrombin Regulation by Physiological Inhibitors: The Role of Vitronectin
In: Seminars in thrombosis and hemostasis. - New York, NY : Thieme Vol. 22, No. 02 (4. 1996), p. 165-172 Zugang:
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1996
The generation of thrombin and its various activities have to be tightly controlled in the circulation as well as at extracellular sites to prevent pathological situations. Both vessel wall-associated thrombomodulin and circulating serine protease inhibitors meet the requirements for regulation... mehr
Hemostatic Protease Receptors and Endothelial Cell Function: Insights from Gene Targeting in Mice
In: Seminars in thrombosis and hemostasis. - New York, NY : Thieme Vol. 26, No. 05 (0. 2000), p. 451-462 Zugang:
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2000
Hemostasis constitutes a major defense system of our body that maintains blood flow in the circulation and prevents life-threatening blood loss. The endothelium plays a crucial dynamic role as a protective interface between blood and the underlying tissues during this process. Following vessel... mehr
The Role of Multifunctional Adhesion Molecules in Spermatogenesis and Sperm Function: Lessons from Hemostasis and Defense?
In: Seminars in thrombosis and hemostasis. - New York, NY : Thieme Vol. 33, No. 01 (2. 2007), p. 100-110 Zugang:
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2007
The functional maintenance of the vascular endothelial cell barrier depends on different homo- and heterotypic adhesion systems involving tight junctions, junctional adhesion proteins, and cadherins. Upon inflammatory responses, vessel wall-dependent adhesion and transmigration of leukocytes... mehr
Binding of thrombin to thrombomodulin accelerates inhibition of the enzyme by antithrombin III. Evidence for a heparin-independent mechanism
In: Biochemistry. - Columbus, Ohio : American Chemical Society, ISSN 1520-4995, Vol. 26, No. 9 (1987), p. 2521-2528 Zugang:
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The role of vitronectin as multifunctional regulator in the hemostatic and immune systems
in: Annals of hematology , ISSN 1432-0584, Vol. 59 (5. 1989), p. 419-431 Zugang:
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1989
Summary Vitronectin (= complement S-protein) belongs to the group of structurally and functionally homologous adhesive proteins (fibrinogen, fibronectin, von Willebrand factor) which are essential in the procoagulant phase of the hemostatic system, interacting with platelets and the vessel wall.... mehr
Functional interaction of plasminogen activator inhibitor type 1 (PAI-1) and heparin
In: Biochemistry. - Columbus, Ohio : American Chemical Society, ISSN 1520-4995, Vol. 30, No. 4 (1991), p. 1021-1028 Zugang:
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The heparin binding domain of S-protein/vitronectin binds to complement components C7, C8, and C9 and perforin from cytolytic T-cells and inhibits their lytic activities
In: Biochemistry. - Columbus, Ohio : American Chemical Society, ISSN 1520-4995, Vol. 27, No. 11 (1988), p. 4103-4109 Zugang:
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Subcutaneous injection of a cyclic peptide antagonist of vitronectin receptor–type integrins inhibits retinal neovascularization
in: Nature medicine . - New York, NY : Nature America Inc., ISSN 1546-170X, Vol. 2, No. 5 (1996), p. 529-533 Zugang:
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1996
Retinal neovascularization is a major cause of blindness in such disorders as retinopathy of prematurity, proliferative diabetic retinopathy and senile macular degeneration. Because ligation of vitronectin receptor–type integrins appears to be required for the survival and maturation of newly... mehr
A simplified functional assay for protein C in plasma samples
in: Annals of hematology , ISSN 1432-0584, Vol. 52 (3. 1986), p. 169-177 Zugang:
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1986
Summary The important role of protein C (PC) in the regulation of hemostasis has been appreciated since the description of patients who were deficient in PC and presented with severe thromboembolic events. The potentially fatal complications associated with PC-deficiency require an early and... mehr
Staphylococcus aureus extracellular adherence protein serves as anti-inflammatory factor by inhibiting the recruitment of host leukocytes
in: Nature medicine . - New York, NY : Nature America Inc., ISSN 1546-170X, Vol. 8, No. 7 (2002), p. 687-693 Zugang:
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2002
Staphylococcus aureus is a human pathogen that secretes proteins that contribute to bacterial colonization. Here we describe the extracellular adherence protein (Eap) as a novel anti-inflammatory factor that inhibits host leukocyte recruitment. Due to its direct interactions with the host... mehr
Angiopoietin-2 sensitizes endothelial cells to TNF-α and has a crucial role in the induction of inflammation
in: Nature medicine . - New York, NY : Nature America Inc., ISSN 1546-170X, Vol. 12, No. 2 (2006), p. 235-239 Zugang:
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2006
The angiopoietins Ang-1 and Ang-2 have been identified as ligands of the receptor tyrosine kinase Tie-2 (refs. 1,2). Paracrine Ang-1–mediated activation of Tie-2 acts as a regulator of vessel maturation and vascular quiescence. In turn, the antagonistic ligand Ang-2 acts by an autocrine... mehr