Differential methylation of genes and retrotransposons facilitates shotgunsequencing of the maize genome
in: Nature genetics . - New York, NY : Nature America, ISSN 1546-1718, Vol. 23, No. 3 (1999), p. 305-308 Zugang:
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1999
The genomes of higher plants and animals are highly differentiated, andare composed of a relatively small number of genes and a large fraction ofrepetitive DNA. The bulk of this repetitive DNA constitutes transposable,and especially retrotransposable, elements.It has been hypothesized that most... mehr
The use of exonuclease III deletions in automated DNA sequencing
in: Methods, in: Methods . - Amsterdam : Elsevier, ISSN 1046-2023, ZDB-ID 1471152-7 Vol. 3, No. 1 (1991), p. 33-40
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Role of transposable elements in heterochromatin and epigenetic control
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 430, No. 6998 (2004), p. 471-476 Zugang:
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2004
Heterochromatin has been defined as deeply staining chromosomal material that remains condensed in interphase, whereas euchromatin undergoes de-condensation. Heterochromatin is found near centromeres and telomeres, but interstitial sites of heterochromatin (knobs) are common in plant genomes and... mehr
Genome-wide in situ exon capture for selective resequencing
in: Nature genetics . - New York, NY : Nature America, ISSN 1546-1718, Vol. 39, No. 12 (2007), p. 1522-1527 Zugang:
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2007
Increasingly powerful sequencing technologies are ushering in an era of personal genome sequences and raising the possibility of using such information to guide medical decisions. Genome resequencing also promises to accelerate the identification of disease-associated mutations. Roughly 98% of... mehr
Caenorhabditis elegans expressed sequence tags identify gene families and potential disease gene homologues
in: Nature genetics . - New York, NY : Nature America, ISSN 1546-1718, Vol. 1, No. 2 (1992), p. 124-131 Zugang:
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1992
A database containing mapped partial cDNA sequences from Caenorhabdhitis elegans will provide a ready starting point for identifying nematode homologues of important human genes and determining their functions in C. elegans. A total of 720 expressed sequence tags (ESTs) have been generated from... mehr
Inactivation of the apoptosis effector Apaf-1 in malignant melanoma
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 409, No. 6817 (2001), p. 207-211 Zugang:
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2001
Metastatic melanoma is a deadly cancer that fails to respond to conventionalchemotherapy and is poorly understood at the molecular level. p53 mutations often occur in aggressive and chemoresistant cancers butare rarely observed in melanoma. Here we show that metastaticmelanomas often lose Apaf-1,... mehr
A map for sequence analysis of the Arabidopsis thaliana genome
in: Nature genetics . - New York, NY : Nature America, ISSN 1546-1718, Vol. 22, No. 3 (1999), p. 265-270 Zugang:
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1999
Arabidopsis thaliana has emerged as a model system for studies ofplant genetics and development, and its genome has been targeted for sequencing by an international consortium (the Arabidopsis Genome Initiative; http://genome-www.stanford.edu/Arabidopsis/agi.html). To supportthe genome-sequencing... mehr
Second-generation shRNA libraries covering the mouse and human genomes
in: Nature genetics . - New York, NY : Nature America, ISSN 1546-1718, Vol. 37, No. 11 (2005), p. 1281-1288 Zugang:
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2005
Loss-of-function phenotypes often hold the key to understanding the connections and biological functions of biochemical pathways. We and others previously constructed libraries of short hairpin RNAs that allow systematic analysis of RNA interference–induced phenotypes in mammalian cells. Here... mehr
A resource for large-scale RNA-interference-based screens in mammals
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 428, No. 6981 (2004), p. 427-431 Zugang:
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2004
Gene silencing by RNA interference (RNAi) in mammalian cells using small interfering RNAs (siRNAs) and short hairpin RNAs (shRNAs) has become a valuable genetic tool. Here, we report the construction and application of a shRNA expression library targeting 9,610 human and 5,563 mouse genes. This... mehr
Initial sequencing and analysis of the human genome
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 409, No. 6822 (2001), p. 860-921 Zugang:
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2001
The human genome holds an extraordinary trove of information about human development, physiology, medicine and evolution. Here we report the results of an international collaboration to produce and make freely available a draft sequence of the human genome. We also present an initial analysis of... mehr
Initial sequencing and comparative analysis of the mouse genome
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 420, No. 6915 (2002), p. 520-562 Zugang:
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2002
The sequence of the mouse genome is a key informational tool for understanding the contents of the human genome and a key experimental tool for biomedical research. Here, we report the results of an international collaboration to produce a high-quality draft sequence of the mouse genome. We also... mehr