Insensitivity to anaesthetic agents conferred by a class of GABA<inf>A</inf> receptor subunit
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 385, No. 6619 (1997), p. 820-823 Zugang:
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1997
A common feature of general anaesthetic agents is their ability to potentiate neuronal inhibition through GABAA (γ-aminobutyric acid) receptors1. At concentrations relevant to clinical anaesthesia, these agents cause a dramatic stimulation of the chloride currents that are evoked by the... mehr
A cytoplasmic region determines single-channel conductance in 5-HT<inf>3</inf> receptors
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 424, No. 6946 (2003), p. 321-324 Zugang:
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2003
5-Hydroxytryptamine type 3 (5-HT3) receptors are cation-selective transmitter-gated ion channels of the Cys-loop superfamily. The single-channel conductance of human recombinant 5-HT3 receptors assembled as homomers of 5-HT3A subunits, or heteromers of 5-HT3A and 5-HT3B subunits, are markedly... mehr
The 5-HT<inf>3B</inf> subunit is a major determinant of serotonin-receptor function
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 397, No. 6717 (1999), p. 359-363 Zugang:
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1999
The neurotransmitter serotonin (5-hydroxytryptamine or 5-HT) mediates rapid excitatory responses through ligand-gated channels (5-HT3 receptors). Recombinant expression of the only identified receptor subunit (5-HT3A) yields functional 5-HT3 receptors. However, the conductance of these homomeric... mehr
The complete genome sequence of the gastric pathogen Helicobacter pylori
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 388, No. 6642 (1997), p. 539-547 Zugang:
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1997
Helicobacter pylori, strain 26695, has a circular genome of 1,667,867 base pairs and 1,590 predicted coding sequences. Sequence analysis indicates that H. pylori has well-developed systems for motility, for scavenging iron, and for DNA restriction and modification. Many putative adhesins,... mehr
The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 390, No. 6658 (1997), p. 364-370 Zugang:
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1997
Archaeoglobus fulgidus is the first sulphur-metabolizing organism to have its genome sequence determined. Its genome of 2,178,400 base pairs contains 2,436 open reading frames (ORFs). The information processing systems and the biosynthetic pathways for essential components (nucleotides, amino... mehr
Genome sequence, comparative analysis and haplotype structure of the domestic dog
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 438, No. 7069 (2005), p. 803-819 Zugang:
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2005
Here we report a high-quality draft genome sequence of the domestic dog (Canis familiaris), together with a dense map of single nucleotide polymorphisms (SNPs) across breeds. The dog is of particular interest because it provides important evolutionary information and because existing breeds show... mehr
Evolution of genes and genomes on the Drosophila phylogeny
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 450, No. 7167 (2007), p. 203-218 Zugang:
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2007
Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the... mehr