Effects of granisetron with doxorubicin or epirubicin on ECG intervals
in: Cancer chemotherapy and pharmacology , ISSN 1432-0843, Vol. 37 (5. 1996), p. 502-504 Zugang:
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1996
Abstract Commercially available serotonin-type 3 (5-HT3) receptor antagonists (ondansetron, granisetron, and tropisetron) have shown no clinically significant adverse effects on the cardiovascular system. In the dose-ranging evaluation of dolasetron, computer-generated ECGs revealed clinically... mehr
Copyright: Copyright 1996 Springer-Verlag Berlin Heidelberg mehr
A common variant in BRCA2 is associated with both breast cancer risk and prenatal viability
in: Nature genetics . - New York, NY : Nature America, ISSN 1546-1718, Vol. 26, No. 3 (2000), p. 362-364 Zugang:
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2000
Inherited mutations in the gene BRCA2 predispose carriers to early onset breast cancer, but such mutations account for fewer than 2% of all cases in East Anglia. It is likely that low penetrance alleles explain the greater part of inherited susceptibility to breast cancer; polymorphic variants in... mehr
A recurrent mutation in PALB2 in Finnish cancer families
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 446, No. 7133 (2007), p. 316-319 Zugang:
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2007
BRCA1, BRCA2 and other known susceptibility genes account for less than half of the detectable hereditary predisposition to breast cancer. Other relevant genes therefore remain to be discovered. Recently a new BRCA2-binding protein, PALB2, was identified. The BRCA2–PALB2 interaction is crucial... mehr
Corrigendum: A common coding variant in CASP8 is associated with breast cancer risk
in: Nature genetics . - New York, NY : Nature America, ISSN 1546-1718, Vol. 39, No. 5 (2007), p. 688-688 Zugang:
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A common coding variant in CASP8 is associated with breast cancer risk
in: Nature genetics . - New York, NY : Nature America, ISSN 1546-1718, Vol. 39, No. 3 (2007), p. 352-358 Zugang:
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2007
The Breast Cancer Association Consortium (BCAC) has been established to conduct combined case-control analyses with augmented statistical power to try to confirm putative genetic associations with breast cancer. We genotyped nine SNPs for which there was some prior evidence of an association with... mehr
Genome-wide association study identifies novel breast cancer susceptibility loci
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 447, No. 7148 (2007), p. 1087-1093 Zugang:
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2007
Breast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility to the disease. Known susceptibility genes account for less than 25% of the familial risk of breast cancer, and the residual genetic variance is likely to be due to variants conferring more moderate... mehr