Identification and characterization of the mouse MutS homolog 5: Msh5
in: Mammalian genome , ISSN 1432-1777, Vol. 10 (11. 1999), p. 1054-1061 Zugang:
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1999
Abstract. We have identified and characterized the complete cDNA and gene for the mouse MutS homolog 5 (Msh5), as a step toward understanding the molecular genetic mechanisms involved in the biological function of this new MutS homologous protein in mammals. The Msh5 cDNA contains a 2502-bp open... mehr
Copyright: Copyright 1999 Springer-Verlag New York Inc. mehr
An analysis of the distribution and dose response of chromosome aberrations in human lymphocytes after in vitro exposure to137Cesium gamma radiation
in: Radiation and environmental biophysics , ISSN 1432-2099, Vol. 22 (1. 1983), p. 33-51 Zugang:
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1983
Summary The chromosome aberration yield for human lymphocytes exposed in vitro to various doses of137Cesium has been studied. Dicentric, total acentric, and excess acentric data were seen to follow a Possion distribution. Calculated total hits demonstrated over-dispersion which could possibly be... mehr
A Matrix Associated Region Localizes the Human SOCS-1 Gene to Chromosome 16p13.13
in: Somatic cell and molecular genetics , ISSN 1572-9931, Vol. 24 (2. 1998), p. 131-133 Zugang:
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1998
Abstract The MarFinder algorithm was applied to a newly sequenced segment of 16p13.13 abutting the 3′ end of the human PRM1 → PRM2 → TNP2 locus. A candidate region of matrix attached was identified. Subsequent biophysical analysis showed that this region was attached to the somatic nuclear... mehr
Copyright: Copyright 1998 Plenum Publishing Corporation mehr
Cytological and molecular characterization of centromeres in Mus domesticus and Mus spretus
in: Mammalian genome , ISSN 1432-1777, Vol. 2 (3. 1992), p. 186-194 Zugang:
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1992
Abstract We have applied EM in situ hybridization (EMISH) and pulsed field gel electrophoresis (PFGE) to samples from diploid primary cell cultures and an established cell line to examine in detail the relative organization of the major and minor satellite DNAs and telomere sequences in the... mehr
Copyright: Copyright 1992 Springer-Verlag New York Inc mehr
The relationship between chromosome structure and function at a human telomeric region
in: Nature genetics . - New York, NY : Nature America, ISSN 1546-1718, Vol. 15, No. 3 (1997), p. 252-257 Zugang:
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1997
We have sequenced a contiguous 284, 495-bp segment of DNA extending from the terminal (TTAGGG)n repeats of the short arm of chromosome 16, providing a full description of the transition from telomeric through subtelomeric DNA to sequences that are unique to the chromosome. To complement and... mehr
Comparison of human genetic and sequence-based physical maps
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 409, No. 6822 (2001), p. 951-953 Zugang:
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2001
Recombination is the exchange of information between two homologous chromosomes during meiosis. The rate of recombination per nucleotide, which profoundly affects the evolution of chromosomal segments, is calculated by comparing genetic and physical maps. Human physical maps have been constructed... mehr
Positional cloning of the Fanconi anaemia group A gene
in: Nature genetics . - New York, NY : Nature America, ISSN 1546-1718, Vol. 14, No. 3 (1996), p. 324-328 Zugang:
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1996
The Fanconi anaemia/Breast cancer consortium*Fanconi anaemia (FA) is an autosomal recessive disorder associated with progressive bone-marrow failure, a variety of congenital abnormalities, and predisposition to acute myeloid leukaemia1. Cells from FA patients show increased sensitivity to... mehr
The sequence and analysis of duplication-rich human chromosome 16
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 432, No. 7020 (2004), p. 988-994 Zugang:
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2004
Human chromosome 16 features one of the highest levels of segmentally duplicated sequence among the human autosomes. We report here the 78,884,754 base pairs of finished chromosome 16 sequence, representing over 99.9% of its euchromatin. Manual annotation revealed 880 protein-coding genes... mehr
A physical map of the human genome
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 409, No. 6822 (2001), p. 934-941 Zugang:
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2001
The human genome is by far the largest genome to be sequenced, and its size and complexity present many challenges for sequence assembly. The International Human Genome Sequencing Consortium constructed a map of the whole genome to enable the selection of clones for sequencing and for the... mehr
Initial sequencing and analysis of the human genome
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 409, No. 6822 (2001), p. 860-921 Zugang:
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2001
The human genome holds an extraordinary trove of information about human development, physiology, medicine and evolution. Here we report the results of an international collaboration to produce and make freely available a draft sequence of the human genome. We also present an initial analysis of... mehr