Involving parents in child sexual abuse prevention programs
in: Journal of child and family studies , ISSN 1573-2843, Vol. 3 (2. 1994), p. 137-142 Zugang:
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1994
Conclusion The importance of involving parents in child sexual abuse prevention programs has been given much lip-service by prevention educators, but relatively little time, energy or resources in reality. This seems short-sighted at best, if the goal of these programs is truly prevention as they... mehr
Copyright: Copyright 1994 Human Sciences Press, Inc. mehr
A randomized evaluation of consumer versus nonconsumer training of state mental health service providers
in: Community mental health journal , ISSN 1573-2789, Vol. 31 (3. 1995), p. 229-238 Zugang:
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1995
Abstract Rreliminary evidence suggests that mental health consumers can successfully serve as peer companions, case management aides, case managers, job coaches, and drop-in center staff. However, few empirical investigations have addressed the use of consumers to train mental health... mehr
Copyright: Copyright 1995 Human Sciences Press, Inc. mehr
A molecular genetic approach to the identification of isochromosomes of chromosome 21
in: Human genetics , ISSN 1432-1203, Vol. 86 (4. 1991), p. 375-382 Zugang:
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1991
Summary The largest class of de novo chromosomal rearrangements in Down syndrome are rea(21q21q). Classically, these rearrangements have been termed Robertsonian translocations, implying an attachment of two different chromosome 21 homologues. Additionally, a Robertsonian translocation between... mehr
Seasonal carbon isotope discrimination in a grassland community
in: Oecologia , ISSN 1432-1939, Vol. 85 (3. 1991), p. 314-320 Zugang:
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1991
Summary Grassland communities of arid western North America are often characterized by a seasonal increase in ambient temperature and evaporative demand and a corresponding decline in soil moisture availability. As the environment changes, particular species could respond differently, which... mehr
Cytotoxicity of gelonin and its conjugates with antibodies is determined by the extent of their endocytosis
in: Journal of Cellular Physiology, in: Journal of Cellular Physiology . - New York, NY [u.a.] : Wiley-Liss, ISSN 0021-9541, ZDB-ID 1478143-8 Vol. 141 (1. 1989), p. 222-234
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1989
Conjugates of the single-chain ribosome-inactivating protein gelonin with ligands that bind to cell surface molecules vary greatly in their cytotoxicity. Conjugates that are not endocytosed after binding to cells exhibit low cytotoxicity similar to that of free gelonin, while conjugates that are... mehr
A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 409, No. 6822 (2001), p. 928-933 Zugang:
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2001
We describe a map of 1.42 million single nucleotide polymorphisms (SNPs) distributed throughout the human genome, providing an average density on available sequence of one SNP every 1.9 kilobases. These SNPs were primarily discovered by two projects: The SNP Consortium and the analysis of clone... mehr
The DNA sequence of human chromosome 7
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 424, No. 6945 (2003), p. 157-164 Zugang:
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2003
Human chromosome 7 has historically received prominent attention in the human genetics community, primarily related to the search for the cystic fibrosis gene and the frequent cytogenetic changes associated with various forms of cancer. Here we present more than 153 million base pairs... mehr
The Collaborative Cross, a community resource for the genetic analysis of complex traits
in: Nature genetics . - New York, NY : Nature America, ISSN 1546-1718, Vol. 36, No. 11 (2004), p. 1133-1137 Zugang:
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2004
The goal of the Complex Trait Consortium is to promote the development of resources that can be used to understand, treat and ultimately prevent pervasive human diseases. Existing and proposed mouse resources that are optimized to study the actions of isolated genetic loci on a fixed background... mehr
Generation and annotation of the DNA sequences of human chromosomes 2 and 4
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 434, No. 7034 (2005), p. 724-731 Zugang:
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2005
Human chromosome 2 is unique to the human lineage in being the product of a head-to-head fusion of two intermediate-sized ancestral chromosomes. Chromosome 4 has received attention primarily related to the search for the Huntington's disease gene, but also for genes associated with... mehr
Initial sequencing and analysis of the human genome
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 409, No. 6822 (2001), p. 860-921 Zugang:
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2001
The human genome holds an extraordinary trove of information about human development, physiology, medicine and evolution. Here we report the results of an international collaboration to produce and make freely available a draft sequence of the human genome. We also present an initial analysis of... mehr
Genome sequence, comparative analysis and haplotype structure of the domestic dog
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 438, No. 7069 (2005), p. 803-819 Zugang:
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2005
Here we report a high-quality draft genome sequence of the domestic dog (Canis familiaris), together with a dense map of single nucleotide polymorphisms (SNPs) across breeds. The dog is of particular interest because it provides important evolutionary information and because existing breeds show... mehr
Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 447, No. 7141 (2007), p. 167-177 Zugang:
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2007
We report a high-quality draft of the genome sequence of the grey, short-tailed opossum (Monodelphis domestica). As the first metatherian (‘marsupial’) species to be sequenced, the opossum provides a unique perspective on the organization and evolution of mammalian genomes. Distinctive... mehr
Initial sequencing and comparative analysis of the mouse genome
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 420, No. 6915 (2002), p. 520-562 Zugang:
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2002
The sequence of the mouse genome is a key informational tool for understanding the contents of the human genome and a key experimental tool for biomedical research. Here, we report the results of an international collaboration to produce a high-quality draft sequence of the mouse genome. We also... mehr