Mapping quantitative trait loci for binary traits using a heterogeneous residual variance model: an application to Marek's disease susceptibility in chickens
in: Genetica , ISSN 1573-6857, Vol. 104 (2. 1998), p. 171-178 Zugang:
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1998
Abstract A typical problem in mapping quantitative trait loci (QTLs) comes from missing QTL genotype. A routine method for parameter estimation involving missing data is the mixture model maximum likelihood method. We developed an alternative QTL mapping method that describes a mixture of several... mehr
Copyright: Copyright 1998 Kluwer Academic Publishers mehr
Expression cloning of a cDNA for the major Fanconi anaemia gene, FAA
in: Nature genetics . - New York, NY : Nature America, ISSN 1546-1718, Vol. 14, No. 3 (1996), p. 320-323 Zugang:
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1996
Fanconi anaemia (FA) is an autosomal recessive disorder characterized by a diversity of clinical symptoms including skeletal abnormalities, progressive bone marrow failure and a marked predisposition to cancer1–4. FA cells exhibit chromosomal instability and hyper-responsiveness to the... mehr
A physical map of the human genome
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 409, No. 6822 (2001), p. 934-941 Zugang:
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2001
The human genome is by far the largest genome to be sequenced, and its size and complexity present many challenges for sequence assembly. The International Human Genome Sequencing Consortium constructed a map of the whole genome to enable the selection of clones for sequencing and for the... mehr
A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 432, No. 7018 (2004), p. 717-722 Zugang:
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2004
We describe a genetic variation map for the chicken genome containing 2.8 million single-nucleotide polymorphisms (SNPs). This map is based on a comparison of the sequences of three domestic chicken breeds (a broiler, a layer and a Chinese silkie) with that of their wild ancestor, red jungle... mehr
Initial sequencing and analysis of the human genome
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 409, No. 6822 (2001), p. 860-921 Zugang:
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2001
The human genome holds an extraordinary trove of information about human development, physiology, medicine and evolution. Here we report the results of an international collaboration to produce and make freely available a draft sequence of the human genome. We also present an initial analysis of... mehr
Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 432, No. 7018 (2004), p. 695-716 Zugang:
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2004
We present here a draft genome sequence of the red jungle fowl, Gallus gallus. Because the chicken is a modern descendant of the dinosaurs and the first non-mammalian amniote to have its genome sequenced, the draft sequence of its genome—composed of approximately one billion base pairs of... mehr