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Verfasser Titel Jahr
zeige Details Uff, C. R., Yiu, C. Y., ... Influence of suture physicochemical and surface topographic structure on tumor cell adherence
in: Diseases of the colon & rectum , ISSN 1530-0358, Vol. 36 (9. 1993), p. 850-854
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Abstract Local recurrence following curative resection for colorectal cancer may be caused by the seeding of free malignant cells at the anastomotic site. This study investigated the influence of suture material on in vitro tumor cell adherence. Radiolabeled rat colonic cancer cells (RCC5) were incubated with a variety of suture materials, and the relative contribution of chemical composition and physical configuration to cell adherence was assessed. Nonadherent cells were washed free, and the cell adherence was determined by radioactive counting. Marked differences in adherence were observed, with cells preferentially adhering to protein-based and multifilament sutures. These observations were confirmed using scanning electron microscopy. These findings indicate that both chemical composition and physical configuration influence the adherence of tumor cells to sutures and suggest that the use of protein-based and multifilament sutures be carefully considered in situations where free malignant cells may be present following colorectal surgery.
Copyright: Copyright 1993 American Society of Colon and Rectal Surgeons
beteiligte Personen: Uff, C. R. , Yiu, C. Y. , Boulos, P. B. , Phillips, R. K. S.
Format: Elektronisch
Erschienen: 1993.
Serie: Springer Online Journal Archives 1860-2000 [Dig. Serial]
Schlagwörter:
URL: http://dx.doi.org/10.1007/BF02047382

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