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zeige Details Cordero Otero, R., Gaillardin, C. Dominant mutations affecting expression of pH-regulated genes inYarrowia lipolytica
in: Molecular genetics and genomics , ISSN 1617-4623, Vol. 252 (3. 1996), p. 311-319
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1996
Abstract In the yeastYarrowia lipolytica the levels of the alkaline extracellular protease (AEP) and acid extracellular protease (AXP) are controlled by the pH of the growth medium. When the pH of growth medium is kept close to 4.0, levels of AXP are high and those of AEP are low, whereas at pH above 6.0 the opposite is true. Mutations which mimic the effects on the protease system of growth at alkaline pH have been identified in two genes,RPH1 andRPH2, inY. lipolytica. Detailed genetic studies showed that mutations in these two genes are dominant in heterozygous diploids, and that their effects are additive in haploid double mutants. These mutants show that pH regulates AEP expression independently from other metabolic signals. These mutants are not detectably affected in their growth rates, nor in internal pH homeostasis.
Copyright: Copyright 1996 Springer-Verlag
beteiligte Personen: Cordero Otero, R. , Gaillardin, C.
Format: Elektronisch
Erschienen: 1996.
Serie: Springer Online Journal Archives 1860-2000 [Dig. Serial]
Schlagwörter:
URL: http://dx.doi.org/10.1007/BF02173777

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zeige Details Otero, Ricardo Cordero, Gaillardin, C. Dominant mutations affecting expression of pH-regulated genes in Yarrowia lipolytica
in: Molecular genetics and genomics , ISSN 1617-4623, Vol. 252 (3. 1996), p. 311-319
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