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zeige Details Heyman, G. M., Monaghan, M. M., ... Low doses of cis-flupentixol attenuate motor performance
in: Psychopharmacology , ISSN 1432-2072, Vol. 93 (4. 1987), p. 477-482
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1987
Abstract We evaluated the effects of cis-flupentixol on reinforced responding. The experimental subjects were rats and the reinforced response was a lever press. The procedure was a five-component multiple schedule that provided five different reinforcement rates. Cis-flupentixol produced dose-dependent decreases in reinforced responding. An equation, the matching law, was fitted to the results. One parameter of this equation represents the estimated response rate asymptote. Cis-flupentixol produced dose-dependent decreases in the asymptotes. A second parameter of the equation represents the rate of reinforcement that maintains a one-half asymptotic response rate. Cis-flupentixol did not appear to affect this measure. There is evidence that the response rate asymptote measures motor components of response rate and that the reinforcement parameter measures the efficacy of the reinforcement maintaining the response. According to these results, cis-flupentixol systematically affected the motor-component of reinforced responding — it slowed down lever pressing — without affecting the subject's sensitivity to the reinforcer maintaining the response. In contrast, other neuroleptics have decreased the subjects' sensitivity to reinforcement, according to the matching law measures.
Copyright: Copyright 1987 Springer-Verlag
beteiligte Personen: Heyman, G. M. , Monaghan, M. M. , Clody, D. E.
Format: Elektronisch
Erschienen: 1987.
Serie: Springer Online Journal Archives 1860-2000 [Dig. Serial]
Schlagwörter:
URL: http://dx.doi.org/10.1007/BF00207238

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