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Verfasser Titel Jahr
zeige Details Gurtu, S., Seth, S., ... Evidence for verapamil-induced functional inhibition of noradrenergic neurotransmission in vivo
in: Naunyn-Schmiedeberg's archives of pharmacology , ISSN 1432-1912, Vol. 345 (2. 1992), p. 172-175
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1992
Summary Contractions of the cat nictitating membrane have been used to explore the effects of calcium channel blockers on neurotransmission in vivo, by comparing the effects of verapamil and nifedipine on contractions of nictitating membrane following either electrical stimulation of the superior cervical ganglion or intravenous injection of the α-adrenoceptor agonist phenylephrine. Verapamil (0.3, 0.6 and 1.2 mg/kg, iv) produced a dose related and reversible inhibition of stimulation induced contractions but did not affect phenylephrine responses of nictitating membrane. Intravenous nifedipine (10, 20 and 40 μg/kg) produced inconsistent effects on both stimulation- and phenylephrine-induced contractions of the nictitating membrane. Thus only verapamil appears to selectively affect noradrenergic neurotransmission in this model, possibly by altering the neurotransmitter release from the terminals innervating the nictitating membrane in the cat.
Copyright: Copyright 1992 Springer-Verlag
beteiligte Personen: Gurtu, S. , Seth, S. , Roychoudhary, A. K.
Format: Elektronisch
Erschienen: 1992.
Serie: Springer Online Journal Archives 1860-2000 [Dig. Serial]
Schlagwörter:
URL: http://dx.doi.org/10.1007/BF00165732

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