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zeige Details Gómez-Puyou, A., Sandoval, F., ... On the locus of action of Na+ at site I of oxidative phosphorylation
in: Journal of bioenergetics and biomembranes , ISSN 1573-6881, Vol. 3 (3/4. 1972), p. 221-233
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Abstract The effect of octylguanidine on the Na+ stimulated oxygen uptake of rat liver mitochondria and bovine heart submitochondrial particles and on the Na+ induced efflux of K from the mitochondria has been examined. The results indicate that the action of Na+ is inhibited by octylguanidine, but that the degree of inhibition depends on the concentration of the cation. Apparently, a competition exists between Na+ and octylguanidine for a common site. Octylguanidine, but not oligomycin, at certain concentrations restores in mitochondria incubated with Na+ the capacity to respond to uncouplers. A competitive effect between monovalent cations and octylguanidine has been observed in submitochondrial particles oxidizing NADH.
Copyright: Copyright 1972 Plenum Publishing Company Limited
beteiligte Personen: Gómez-Puyou, A. , Sandoval, F. , Gómez-Puyou, M. Tuena , Chávez, E. , Pinto, E.
Format: Elektronisch
Erschienen: 1972.
Serie: Springer Online Journal Archives 1860-2000 [Dig. Serial]
Schlagwörter:
URL: http://dx.doi.org/10.1007/BF01515970

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