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Verfasser Titel Jahr
zeige Details Stephens, Philip, Edkins, Sarah, ... A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer
in: Nature genetics . - New York, NY : Nature America, ISSN 1546-1718, Vol. 37, No. 6 (2005), p. 590-592
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2005
We examined the coding sequence of 518 protein kinases, ∼1.3 Mb of DNA per sample, in 25 breast cancers. In many tumors, we detected no somatic mutations. But a few had numerous somatic mutations with distinctive patterns indicative of either a mutator phenotype or a past exposure.
beteiligte Personen: Stephens, Philip , Edkins, Sarah , Davies, Helen , Greenman, Chris , Cox, Charles , Hunter, Chris , Bignell, Graham , Teague, Jon , Smith, Raffaella , Stevens, Claire , O'Meara, Sarah , Parker, Adrian , Tarpey, Patrick , Avis, Tim , Barthorpe, Andy , Brackenbury, Lisa , Buck, Gemma , Butler, Adam , Clements, Jody , Cole, Jennifer , Dicks, Ed , Edwards, Ken , Forbes, Simon , Gorton, Matthew , Gray, Kristian , Halliday, Kelly , Harrison, Rachel , Hills, Katy , Hinton, Jonathon , Jones, David , Kosmidou, Vivienne , Laman, Ross , Lugg, Richard , Menzies, Andrew , Perry, Janet , Petty, Robert , Raine, Keiran , Shepherd, Rebecca , Small, Alexandra , Solomon, Helen , Stephens, Yvonne , Tofts, Calli , Varian, Jennifer , Webb, Anthony , West, Sofie , Widaa, Sara , Yates, Andrew , Brasseur, Francis , Cooper, Colin S , Flanagan, Adrienne M , Green, Anthony , Knowles, Maggie , Leung, Suet Y , Looijenga, Leendert H J , Malkowicz, Bruce , Pierotti, Marco A , Teh, Bin , Yuen, Siu T , Nicholson, Andrew G , Lakhani, Sunil , Easton, Douglas F , Weber, Barbara L , Stratton, Michael R , Futreal, P Andrew , Wooster, Richard
Format: Elektronisch
Erschienen: 2005.
Serie: Nature Archives 1869 - 2007 [Dig. Serial]
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URL: http://dx.doi.org/10.1038/ng1571

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