Anmelden/Registrieren
Zurück zur geteilten Ansicht
Verfasser Titel Jahr
zeige Details Easton, Douglas F., Pooley, Karen A., ... Genome-wide association study identifies novel breast cancer susceptibility loci
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 447, No. 7148 (2007), p. 1087-1093
Zugang: zum Volltext
ähnliche Vorschläge
2007
Breast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility to the disease. Known susceptibility genes account for less than 25% of the familial risk of breast cancer, and the residual genetic variance is likely to be due to variants conferring more moderate risks. To identify further susceptibility alleles, we conducted a two-stage genome-wide association study in 4,398 breast cancer cases and 4,316 controls, followed by a third stage in which 30 single nucleotide polymorphisms (SNPs) were tested for confirmation in 21,860 cases and 22,578 controls from 22 studies. We used 227,876 SNPs that were estimated to correlate with 77% of known common SNPs in Europeans at r2 > 0.5. SNPs in five novel independent loci exhibited strong and consistent evidence of association with breast cancer (P < 10-7). Four of these contain plausible causative genes (FGFR2, TNRC9, MAP3K1 and LSP1). At the second stage, 1,792 SNPs were significant at the P < 0.05 level compared with an estimated 1,343 that would be expected by chance, indicating that many additional common susceptibility alleles may be identifiable by this approach.
beteiligte Personen: Easton, Douglas F. , Pooley, Karen A. , Dunning, Alison M. , Pharoah, Paul D. P. , Thompson, Deborah , Ballinger, Dennis G. , Struewing, Jeffery P. , Morrison, Jonathan , Field, Helen , Luben, Robert , Wareham, Nicholas , Ahmed, Shahana , Healey, Catherine S. , Bowman, Richard , Luccarini, Craig , Conroy, Don , Shah, Mitul , Munday, Hannah , Jordan, Clare , Perkins, Barbara , West, Judy , Redman, Karen , Driver, Kristy , Meyer, Kerstin B. , Haiman, Christopher A. , Kolonel, Laurence K. , Henderson, Brian E. , Le Marchand, Loic , Brennan, Paul , Sangrajrang, Suleeporn , Gaborieau, Valerie , Odefrey, Fabrice , Shen, Chen-Yang , Wu, Pei-Ei , Wang, Hui-Chun , Eccles, Diana , Evans, D. Gareth , Peto, Julian , Fletcher, Olivia , Johnson, Nichola , Seal, Sheila , Stratton, Michael R. , Rahman, Nazneen , Chenevix-Trench, Georgia , Bojesen, Stig E. , Nordestgaard, Børge G. , Axelsson, Christen K. , Garcia-Closas, Montserrat , Brinton, Louise , Chanock, Stephen , Lissowska, Jolanta , Peplonska, Beata , Nevanlinna, Heli , Fagerholm, Rainer , Eerola, Hannaleena , Kang, Daehee , Yoo, Keun-Young , Noh, Dong-Young , Ahn, Sei-Hyun , Hunter, David J. , Hankinson, Susan E. , Cox, David G. , Hall, Per , Wedren, Sara , Liu, Jianjun , Low, Yen-Ling , Bogdanova, Natalia , Schürmann, Peter , Dörk, Thilo , Tollenaar, Rob A. E. M. , Jacobi, Catharina E. , Devilee, Peter , Klijn, Jan G. M. , Sigurdson, Alice J. , Doody, Michele M. , Alexander, Bruce H. , Zhang, Jinghui , Cox, Angela , Brock, Ian W. , MacPherson, Gordon , Reed, Malcolm W. R. , Couch, Fergus J. , Goode, Ellen L. , Olson, Janet E. , Meijers-Heijboer, Hanne , van den Ouweland, Ans , Uitterlinden, André , Rivadeneira, Fernando , Milne, Roger L. , Ribas, Gloria , Gonzalez-Neira, Anna , Benitez, Javier , Hopper, John L. , McCredie, Margaret , Southey, Melissa , Giles, Graham G. , Schroen, Chris , Justenhoven, Christina , Brauch, Hiltrud , Hamann, Ute , Ko, Yon-Dschun , Spurdle, Amanda B. , Beesley, Jonathan , Chen, Xiaoqing , Aghmesheh, Morteza , Amor, David , Andrews, Lesley , Antill, Yoland , Armes, Jane , Armitage, Shane , Arnold, Leanne , Balleine, Rosemary , Begley, Glenn , Beilby, John , Bennett, Ian , Bennett, Barbara , Berry, Geoffrey , Blackburn, Anneke , Brennan, Meagan , Brown, Melissa , Buckley, Michael , Burke, Jo , Butow, Phyllis , Byron, Keith , Callen, David , Campbell, Ian , Chenevix-Trench, Georgia , Clarke, Christine , Colley, Alison , Cotton, Dick , Cui, Jisheng , Culling, Bronwyn , Cummings, Margaret , Dawson, Sarah-Jane , Dixon, Joanne , Dobrovic, Alexander , Dudding, Tracy , Edkins, Ted , Eisenbruch, Maurice , Farshid, Gelareh , Fawcett, Susan , Field, Michael , Firgaira, Frank , Fleming, Jean , Forbes, John , Friedlander, Michael , Gaff, Clara , Gardner, Mac , Gattas, Mike , George, Peter , Giles, Graham , Gill, Grantley , Goldblatt, Jack , Greening, Sian , Grist, Scott , Haan, Eric , Harris, Marion , Hart, Stewart , Hayward, Nick , Hopper, John , Humphrey, Evelyn , Jenkins, Mark , Jones, Alison , Kefford, Rick , Kirk, Judy , Kollias, James , Kovalenko, Sergey , Lakhani, Sunil , Leary, Jennifer , Lim, Jacqueline , Lindeman, Geoff , Lipton, Lara , Lobb, Liz , Maclurcan, Mariette , Mann, Graham , Marsh, Deborah , McCredie, Margaret , McKay, Michael , Anne McLachlan, Sue , Meiser, Bettina , Milne, Roger , Mitchell, Gillian , Newman, Beth , O’Loughlin, Imelda , Osborne, Richard , Peters, Lester , Phillips, Kelly , Price, Melanie , Reeve, Jeanne , Reeve, Tony , Richards, Robert , Rinehart, Gina , Robinson, Bridget , Rudzki, Barney , Salisbury, Elizabeth , Sambrook, Joe , Saunders, Christobel , Scott, Clare , Scott, Elizabeth , Scott, Rodney , Seshadri, Ram , Shelling, Andrew , Southey, Melissa , Spurdle, Amanda , Suthers, Graeme , Taylor, Donna , Tennant, Christopher , Thorne, Heather , Townshend, Sharron , Tucker, Kathy , Tyler, Janet , Venter, Deon , Visvader, Jane , Walpole, Ian , Ward, Robin , Waring, Paul , Warner, Bev , Warren, Graham , Watson, Elizabeth , Williams, Rachael , Wilson, Judy , Winship, Ingrid , Young, Mary Ann , Bowtell, David , Green, Adele , deFazio, Anna , Chenevix-Trench, Georgia , Gertig, Dorota , Webb, Penny , Mannermaa, Arto , Kosma, Veli-Matti , Kataja, Vesa , Hartikainen, Jaana , Day, Nicholas E. , Cox, David R. , Ponder, Bruce A. J.
Format: Elektronisch
Erschienen: 2007.
Serie: Nature Archives 1869 - 2007 [Dig. Serial]
Schlagwörter:
URL: http://dx.doi.org/10.1038/nature05887

Ähnliche Vorschläge

Zurück zur geteilten Ansicht
Verfasser Titel Jahr
zeige Details Hunter, David J, Kraft, Peter, ... A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer
in: Nature genetics . - New York, NY : Nature America, ISSN 1546-1718, Vol. 39, No. 7 (2007), p. 870-874
Zugang: zum Volltext
ähnliche Vorschläge
2007
zeige Details Altshuler, David, Daly, Mark Guilt beyond a reasonable doubt
in: Nature genetics . - New York, NY : Nature America, ISSN 1546-1718, Vol. 39, No. 7 (2007), p. 813-815
Zugang: zum Volltext
ähnliche Vorschläge
2007
zeige Details Van Steen, Kristel, McQueen, Matthew B, ... Genomic screening and replication using the same data set in family-based association testing
in: Nature genetics . - New York, NY : Nature America, ISSN 1546-1718, Vol. 37, No. 7 (2005), p. 683-691
Zugang: zum Volltext
ähnliche Vorschläge
2005
zeige Details Cheung, Vivian G., Spielman, Richard S., ... Mapping determinants of human gene expression by regional and genome-wide association
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 437, No. 7063 (2005), p. 1365-1369
Zugang: zum Volltext
ähnliche Vorschläge
2005
zeige Details Burton, Paul R., Clayton, David G., ... Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 447, No. 7145 (2007), p. 661-678
Zugang: zum Volltext
ähnliche Vorschläge
2007