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Verfasser Titel Jahr
zeige Details Davis, John B., Gray, Julie, ... Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 405, No. 6783 (2000), p. 183-187
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2000
The vanilloid receptor-1 (VR1) is a ligand-gated, non-selective cationchannel expressed predominantly by sensory neurons. VR1 responds to noxiousstimuli including capsaicin, the pungent component of chilli peppers, heatand extracellular acidification, and it is able to integrate simultaneousexposure to these stimuli. These findings and research linkingcapsaicin with nociceptive behaviours (that is, responses to painful stimuliin animals have led to VR1 being considered as important forpain sensation. Here we have disrupted the mouse VR1 gene using standard genetargeting techniques. Small diameter dorsal root ganglion neurons isolatedfrom VR1-null mice lacked many of the capsaicin-, acid- and heat-gated responsesthat have been previously well characterized in small diameter dorsal rootganglion neurons from various species. Furthermore, although the VR1-nullmice appeared normal in a wide range of behavioural tests, including responsesto acute noxious thermal stimuli, their ability to develop carrageenan-inducedthermal hyperalgesia was completely absent. We conclude that VR1 is requiredfor inflammatory sensitization to noxious thermal stimuli but also that alternativemechanisms are sufficient for normal sensation of noxious heat.
beteiligte Personen: Davis, John B. , Gray, Julie , Gunthorpe, Martin J. , Hatcher, Jonathan P. , Davey, Phil T. , Overend, Philip , Harries, Mark H. , Latcham, Judi , Clapham, Colin , Atkinson, Kirsty , Hughes, Stephen A. , Rance, Kim , Grau, Evelyn , Harper, Alex J. , Pugh, Perdita L. , Rogers, Derek C. , Bingham, Sharon , Randall, Andrew , Sheardown, Steven A.
Format: Elektronisch
Erschienen: 2000.
Serie: Nature Archives 1869 - 2007 [Dig. Serial]
Schlagwörter:
URL: http://dx.doi.org/10.1038/35012076

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