Anmelden/Registrieren
Zurück zur geteilten Ansicht
Verfasser Titel Jahr
zeige Details Sablin, Elena P., Jon Kull, F., ... Crystal structure of the motor domain of the kinesin-related motor ncd
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 380, No. 6574 (1996), p. 555-559
Zugang: zum Volltext
ähnliche Vorschläge
1996
MICROTUBULE-BASED ATPases of the kinesin superfamily1,2 provide the motile force for many animated features of living cells. Kinesin motors differ in their direction of movement along microtubules. Kinesin3 and ncd4,5, a kinesin-related motor involved in formation and maintenance of mitotic and meiotic spindles, move in opposite directions along microtubules, even though their motor domains are 40% identical in amino-acid sequence. Here we report the crystal structure of the MgADP complex of the Drosophila ncd motor domaindetermined to 2.5 Å by X-ray crystallography, and compare it to the kinesin structure. The ncd and kinesin motor domains are remarkably similar in structure, and the locations of conserved surface amino acids suggest these motors share a common microtubule-binding site. Moreover, structural and functional comparisons of ncd, kinesin, myosin and G proteins indicate that these NTPases may have a similar strategy of changing conformation between NTP and NDP states. We propose a general model for converting a common γ-phosphate-sensing mechanism into opposite polarities of movementfor kinesin and ncd.
beteiligte Personen: Sablin, Elena P. , Jon Kull, F. , Cooke, Roger , Vale, Ronald D. , Fletterick, Robert J.
Format: Elektronisch
Erschienen: 1996.
Serie: Nature Archives 1869 - 2007 [Dig. Serial]
Schlagwörter:
URL: http://dx.doi.org/10.1038/380555a0

Ähnliche Vorschläge

Zurück zur geteilten Ansicht
Verfasser Titel Jahr
zeige Details Endow, Sharyn A., Higuchi, Hideo A mutant of the motor protein kinesin that moves in both directions onmicrotubules
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 406, No. 6798 (2000), p. 913-916
Zugang: zum Volltext
ähnliche Vorschläge
2000
zeige Details Kashlna, A. S., Baskin, R. J., ... A bipolar kinesin
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 379, No. 6562 (1996), p. 270-272
Zugang: zum Volltext
ähnliche Vorschläge
1996
zeige Details Jon Kull, F., Sablin, Elena P., ... Crystal structure of the kinesin motor domain reveals a structural similarity to myosin
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 380, No. 6574 (1996), p. 550-555
Zugang: zum Volltext
ähnliche Vorschläge
1996
zeige Details Hirose, K., Amos, L. A. Three-dimensional structure of motor molecules
in: Cellular and molecular life sciences , ISSN 1420-9071, Vol. 56 (3/4. 1999), p. 184-199
Zugang: zum Volltext
ähnliche Vorschläge
1999
zeige Details Asenjo, Ana B, Krohn, Natan, ... Configuration of the two kinesin motor domains during ATP hydrolysis
in: Nature structural biology . - New York, NY : Nature America, ISSN 1072-8368, Vol. 10, No. 10 (2003), p. 836-842
Zugang: zum Volltext
ähnliche Vorschläge
2003