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Verfasser Titel Jahr
zeige Details Lok, Si, Kaushansky, Kenneth, ... Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo
in: Nature . - London [u.a.] : Nature Publising Group, ISSN 1476-4687, Vol. 369, No. 6481 (1994), p. 565-568
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1994
THE major regulator of circulating platelet levels is believed to be a cytokine termed thrombopoietin1,2. It is thought to be a lineage-specific cytokine affecting the proliferation and maturation of committed cells resulting in the production of megakaryocytes and platelets. Despite considerable efforts by a number of laboratories, the unequivocal identification of thrombopoietin has proven elusive. Here we report the functional cloning of a murine complementary DNA encoding a ligand for the receptor encoded by the c-mpl proto-oncogene (c-Mpl) 3–5. The encoded polypeptide has a predicted molecular mass of 35,000 (Mr 35K). The protein has a novel two-domain structure with an amino-terminal domain homologous with erythropoietin and a carboxy-terminal domain rich in serine, threonine and proline residues and containing seven potential N-linked glycosylation sites. Intraperitoneal injections of mice with recombinant protein increase circulating platelet levels by greater than fourfold after 7 days. These results along with those presented in the accompanying report strongly suggest that the ligand for c-Mpl is thrombopoietin.
beteiligte Personen: Lok, Si , Kaushansky, Kenneth , Holly, Richard D. , Kuijper, Joseph L. , Lofton-Day, Catherine E. , Oort, Pieter J. , Grant, Francis J. , Heipel, Mark D. , Burkhead, Steve K. , Kramer, Janet M. , Bell, L. Anne , Sprecher, Cindy A. , Blumberg, Hal , Johnson, Rebecca , Prunkard, Donna , Ching, Andrew F. T. , Mathewes, Shannon L. , Bailey, Mason C. , Forstrom, John W. , Buddle, Michele M. , Osborn, Sherri G. , Evans, Simon J. , Sheppard, Paul O. , Presnell, Scott R. , O'Hara, Patrick J. , Hagen, Fredrick S. , Roth, Gerald J. , Foster, Donald C.
Format: Elektronisch
Erschienen: 1994.
Serie: Nature Archives 1869 - 2007 [Dig. Serial]
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URL: http://dx.doi.org/10.1038/369565a0

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